Welcome to the Working Group on New TB Drugs Blog
TB R&D Weekly Update: TB Drug Updates in Future Medicinal Chemistry
Last week we posted information about two special issues of Future Medicinal Chemistry focused on neglected diseases. Future Medicinal Chemistry (September 2011, Volume 3, Number 11) have a few articles on tuberculosis drug development. Additional links to TB R&D news are included.
New TB Materials and Tools Available!
Over the last week, some announcements have been released concerning new tools, publications and meeting materials that may be of value to the TB community including materials from the WGND sponsored “Essentiality of Pyrazinamide” Workshop, an interactive map of clinical trials from PACTR, and a new Collaborative Framework for Care and Control of Tuberculosis and Diabetes from the WHO and The Union.
TB R&D Weekly Update: Future Medicinal Chemistry Features Neglected Diseases
The August and September issues of Future Medicinal Chemistry will focus on neglected diseases including tuberculosis. The issue includes articles from TB researchers including Ann Ginsberg and Takushi Kaneko. Additional links to TB R&D news are included
Global Fund Round 11 Launched!
The Stop TB Partnership has provided information and references to help partners to prepare a successful proposal to The Global Fund to Fight HIV/AIDS, Tuberculosis, and Malaria. The call for Round 11 applications was released on August 15. Go to http://www.stoptb.org/global/tbfriends/ to get more information.
TB R&D Weekly Update: New Target Identified for Pyrazinamide
This week we highlight an article published out of Ying Zhang’s laboratory at Johns Hopkins University that puts forth a new model for the mode of action of pyrazinamide (PZA) and as well as suggest trans-translation as a potential target to consider in the development of new drugs for TB. Additional links to TB R&D news are included.
Posted in Regulations and Guidelines, TB Prevention and Control Strategies, TB Treatment
Updated WHO guidelines on Drug-Resistant TB
The WHO issued updated guidelines on the programmatic management of drug-resistant TB on August 4, 2011 online in the European Respiratory Journal.
Report: The Millenium Development Goals 2011
The United Nations (UN) released a report on July 12 on the progress made thus far on the 8 Millennium Development Goals (MDGs). The eight MDGs include: end poverty and hunger, universal education, gender equality, child health, maternal health, combat HIV/AIDS, environmental sustainability, and global partnership. Key highlights and additional coverage on the report are included.
TB R&D Weekly Update: Some Multidrug-resistant Bacteria More Fit
This week we have an article by researchers from Portugal that suggests that in the case of resistance conferred by plasmids that in some cases resistant bacteria increases its ability to replicate and overall fitness compared to susceptible bacteria. This may complicate research and control efforts to address the rising problem of multi-drug resistance. Additional links to TB R&D News are included.
News from the TB Treatment Field
Recent articles from around the globe related to governments addressing problems with providing treatment services to those with tuberculosis
Posted in Early Drug Development, Front Lines of TB R&D, TB Drug Development, Uncategorized
TB R&D Weekly Update: Novel Compounds Screened for DS and MDR-TB
This week’s featured article from Bill Jacob’s lab looks at novel InhA (target of isoniazid (INH), a first-line TB drug) inhibitors and their ability to kill M. tuberculosis (M.tb) that is drug-sensitive, resistant and in dormant stage. Two compounds were identified that had significant bactericidal activity against M.tb: CD 39 and CD117. Additional links to TB R&D News are included.
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Toppix TB News- Editorial: Lives at risk if the U.S. shortchanges Global Fund 4 Feb 2012
- Multidrug-Resistant Tuberculosis - Update 3 Feb 2012
- Multidrug-Resistant Tuberculosis - Update 3 Feb 2012
- WHO says TB in Russia displays highest known drug resistance 3 Feb 2012
- Media outlets examine Global Fund's future as it enters second decade 3 Feb 2012
