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Working Group on New TB Drugs

Stop TB Partnership

21 Jul 2011

Interview with TB Alert’s Mike Mandelbaum

Mike Mandelbaum, Chief Executive, TB Alert

Mike Mandelbaum is Chief Executive of TB Alert, which is the UK’s National and International Tuberculosis charity – the only British charity working solely on fighting TB in the UK and overseas.

TB R&D Weekly Update: P27-P55 Operon of Mtb and Drug Resistance

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his week, we present an article from researchers from the Instituto de Biotecnologia and TB Control Program in Buenos Aires, Argentina. The article focuses on the P27-P55 operon which has been shown in mice to be essential for M. tuberculosis (M. tb) to survive in the host. Additional links to TB R&D news are included.

14 Jul 2011

Report: An Evaluation of DR-TB Treatment Scale-up

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MSF, PIH, and TAG release a report on MDR-TB scale up that shows poor progress that is leading to spread of MDR-TB and the continued loss of lives.

12 Jul 2011
by Working Group

Posted in TB Drug Development, TB News

TB R&D Weekly Update: Early bactericidal activity of OPC-67683

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This week, we review a recent article published in the July issue of IJTLD on the TB drug candidate OPC-67683 whose new generic name is delamanid. Diacon, et al., present data showing that delamanid is safe, well-tolerated with significant early bactericidal activity. Links to additional TB R&D news is included.

TB R&D Weekly Update: Latent TB Treatment in HIV and Children

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In the July 7 issue of the New England Journal, two articles and an editorial on latent TB and TB prevention are published. One study discusses positive results on a treatment for latent TB in HIV-infected persons. The other study discusses negative findings that isoniazid is not effective in latent treatment of tuberculosis in children regardless of HIV status. A link to MedPage Today is included that provides a good overview of these studies and the editorial. Additional TB R&D News Links also are included.

Video: Jenniffer Dietrich, Challenge Facility for Civil Society

Jenniffer Dietrich, Stop TB Partnership

Jenniffer Dietrich is Technical Officer at the Challenge Facility for Civil Society of the Stop TB Partnership.

28 Jun 2011
by Working Group

Posted in TB Diagnostics, TB Treatment

TB R&D Weekly Update: Tuberculosis and Cancer

A Dowsett, Health Protection Agency/Science Photo Library

This week we review a commentary on the correlations between tuberculosis and cancer, specifically lung cancer. The article appeared in the June issue of Lancet Oncology. Additional links to TB R&D News are included.

Video: Global Fund in the Dominican Republic

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This video documents what the Global Fund has done and can do more of to save lives and prevent infections by engaging affected communities.

21 Jun 2011
by Christopher Cooper

Posted in Early Drug Development, TB Drug Development

TB R&D Weekly Update: Potential Use of Polyether Ionophores Against TB

polyether ionophores

During this week’s TB R&D Weekly Update, we explore the potential of polyether ionophores as anti-tuberculosis agents in an article published in 2009 by Kevin, et al. Links to additional TB R&D News are included.

Video: Global Fund Impact in Indonesia

This video presents interviews with a diverse range of stakeholders on the positive impact that Global Fund financing has had for Indonesia’s national programme. This post also includes another perspective from Kenya.