Welcome to the Working Group on New TB Drugs Blog
Working Group on New TB Drugs Launches Strategic Plan 2011-2015
The WGND Strategic Plan 2011-2015 is an update of the “New Drugs” section of the Global Plan to Stop TB: 2011-2015. It describes the progress, gaps, and vision of the WGND and the TB drug development field as a whole.
Death of TB Champion, Rep. Donald Payne
U.S. Representative Donald Payne from New Jersey died Tuesday, March 6. He will be remembered as a great champion of TB as well as malaria and HIV/AIDS.
TB R&D Weekly Update: CSU Identifies Anti-TB Compound against Unique Target
This week’s article highlights research out of Colorado State University that identifies a potential anti-TB compound against a unique target– the inner membrane transporter MmpL3 of Mycobacterium tuberculosis–that inhibits an essential cell function of the mycobacteria. Additional links to TB R&D News are included.
4th Annual G-FINDER Survey Released
Today, the fourth annual G-FINDER survey tracking funding for research and development of neglected disease technologies was released. This year’s report shows that funding for product development is on the decline and product development partnerships (PDPs) have been particularly hard hit, as eight of the top twelve public donors cut their funding in 2010. Now is a time of tremendous opportunity, with dozens of potential products within the reach of patients–donors must commit to taking them across the finish line.
International TB Research Roadmap Launched!
A plan targeting researchers around the world and providing them with a framework to achieve the research objectives of the the Global Plan to Stop TB 2011-2015 and beyond, towards elimination of TB, was launched on Saturday at the Union World Conference on Lung Health.
Press Release! WHO Warns of Consequences of Underfunding TB
The World Health Organization (WHO) reports for the first time that the number of people falling ill with tuberculosis (TB) each year is declining. New data, published today in the WHO 2011 Global Tuberculosis Control Report, also show that the number of people dying from the disease fell to its lowest level in a decade.
Global Fund Round 11 Launched!
The Stop TB Partnership has provided information and references to help partners to prepare a successful proposal to The Global Fund to Fight HIV/AIDS, Tuberculosis, and Malaria. The call for Round 11 applications was released on August 15. Go to http://www.stoptb.org/global/tbfriends/ to get more information.
Posted in Early Drug Development, Front Lines of TB R&D, TB Drug Development, TB Treatment
TB R&D Weekly Update: Efflux and Rifampicin Resistance
This week we look again at the role of efflux pumps in resistance to anti-tuberculosis drugs. Louw, et al., sought to “demonstrate that the level of rifampicin resistance is defined by efflux, which regulates the intracellular concentration of rifampicin.” This is a shift from the current thinking in the field that rifampicin resistance is solely the result of mutations in the rpoB gene. The article entitled “Rifampicin Reduces Susceptibility to Ofloxacin in Rifampicin Resistant Mycobacterium tuberculosis through Efflux” was published ahead of print in the American Journal of Respiratory and Critical Care Medicine. Additional links to TB R&D News is included.
Posted in Action, Announcements, Events, TB News, TB Prevention and Control Strategies, TB Treatment
Call to Action–Save a million lives by 2015
On June 6, 2011, the Stop TB Partnership launched the initiative Time to Act–Save a Million Lives by 2015 at the UN Headquarters at a reception hosted by Ray Chambers, the UN Secretary-General’s Special Envoy for Malaria and UN MDG Advocate. If you would like to respond to this call to action, visit www.action.org.
Stop TB Partnership’s Coordinating Board Meets in DC
Today was the opening of the 2-day Stop TB Partnership’s Coordinating Board (CB) meeting in Washington, D.C. which included welcoming remarks by Dr. Rajiv Shah (Administrator, USAID), Ms. Lois Quam (Executive Director, GHI), and Dr. Howard Koh (Assistant Secretary, U.S. Depart. of HHS).
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Toppix TB News- Calif. Man Is Criminally Charged to Force Compliance with Tuberculosis Treatment Plan 18 May 2012
- Indian Hospital patients share stories to help heal 17 May 2012
- West Springfield women honored for working with immigrants to prevent tuberculosis 15 May 2012
- MSF says additional resources needed to improve ART access in Burma 11 May 2012
- World disease fund gets added $1.6 bln shot in arm 9 May 2012
