Welcome to the Working Group on New TB Drugs Blog
TB R&D Weekly Update: Tailoring TB Treatment Based on Host Genotype?
This week we have research out of the Ramakrishnan Laboratory that challenges thinking around tuberculosis treatment and considerations of host genotypes. Additional links to TB R&D news are included.
TB R&D Weekly Update: Totally Drug-Resistant TB
Over the past couple of weeks there have been much discussion and reporting on totally drug-resistant tuberculosis (TDR-TB) based on reports of new cases in India. Here are links to coverage of TDR-TB in India, excerpt from a response by Dr. Nardell who we interviewed last year, and link to the WHO Fact Sheet on TDR-TB. Additional links to TB R&D News are included.
WHO Alarmed by Rising Rates of Drug-Resistant TB in Europe
Yesterday, BBC News published an article on the WHO Plan entitled “Consolidated action plan to prevent and combat multidrug- and extensively drug-resistant tuberculosis in the WHO European Region 2011–2015.” The plan outlines the problem as well as a solution that could save 120,000 lives if successful.
Posted in Regulations and Guidelines, TB Prevention and Control Strategies, TB Treatment
Updated WHO guidelines on Drug-Resistant TB
The WHO issued updated guidelines on the programmatic management of drug-resistant TB on August 4, 2011 online in the European Respiratory Journal.
Report: The Millenium Development Goals 2011
The United Nations (UN) released a report on July 12 on the progress made thus far on the 8 Millennium Development Goals (MDGs). The eight MDGs include: end poverty and hunger, universal education, gender equality, child health, maternal health, combat HIV/AIDS, environmental sustainability, and global partnership. Key highlights and additional coverage on the report are included.
News from the TB Treatment Field
Recent articles from around the globe related to governments addressing problems with providing treatment services to those with tuberculosis
Report: An Evaluation of DR-TB Treatment Scale-up
MSF, PIH, and TAG release a report on MDR-TB scale up that shows poor progress that is leading to spread of MDR-TB and the continued loss of lives.
TB R&D Weekly Update: Tuberculosis and Cancer
This week we review a commentary on the correlations between tuberculosis and cancer, specifically lung cancer. The article appeared in the June issue of Lancet Oncology. Additional links to TB R&D News are included.
Posted in TB Prevention and Control Strategies, Video, Voices from the Fight to Stop Tuberculosis
Video: Global Fund Impact in Indonesia
This video presents interviews with a diverse range of stakeholders on the positive impact that Global Fund financing has had for Indonesia’s national programme. This post also includes another perspective from Kenya.
Posted in Early Drug Development, Front Lines of TB R&D, TB Drug Development, TB Treatment
TB R&D Weekly Update: Efflux and Rifampicin Resistance
This week we look again at the role of efflux pumps in resistance to anti-tuberculosis drugs. Louw, et al., sought to “demonstrate that the level of rifampicin resistance is defined by efflux, which regulates the intracellular concentration of rifampicin.” This is a shift from the current thinking in the field that rifampicin resistance is solely the result of mutations in the rpoB gene. The article entitled “Rifampicin Reduces Susceptibility to Ofloxacin in Rifampicin Resistant Mycobacterium tuberculosis through Efflux” was published ahead of print in the American Journal of Respiratory and Critical Care Medicine. Additional links to TB R&D News is included.
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Toppix TB News- Editorial: Lives at risk if the U.S. shortchanges Global Fund 4 Feb 2012
- Multidrug-Resistant Tuberculosis - Update 3 Feb 2012
- Multidrug-Resistant Tuberculosis - Update 3 Feb 2012
- WHO says TB in Russia displays highest known drug resistance 3 Feb 2012
- Media outlets examine Global Fund's future as it enters second decade 3 Feb 2012
