| Recombinant Protein Name / Gene ID | Soluble? | Truncated? | Mutant? | PubMed References |
|---|---|---|---|---|
| 3-oxoacyl-[acyl-carrier protein] reductase / 886551 | Yes | No |
Sophie Lagrange sophie.lagrange@sanofi-aventis.com
| EC number EC 1.1.1.100 |
Genbank accession NP_215999 / P0A5Y4 |
Rv number Rv1483 |
| Validated by: Genetically (in vitro or in vivo) |
PubMed References J. Bacteriology 2007 vol189 10 3721-3728Microbiology 2002 148 951-960 |
| Recombinant Protein Name / Gene ID | Soluble? | Truncated? | Mutant? | PubMed References |
|---|---|---|---|---|
| 3-oxoacyl-[acyl-carrier protein] reductase / 886551 | Yes | No |
| Assay Name | Readout | Format | PubMed References |
|---|---|---|---|
| NADPH consumption assessment | Fluorescence | 96-well plate | |
| NADPH-dependent tetrazolium reduction | Absorbance | 96-well plate |
| Library Name/Indentifier | Total # of Compounds | Screened | HTS Cut Off (ie. 40 um) | # of Hits | # of Leads | PubMed References |
|---|---|---|---|---|---|---|
| Sanofi aventis library XXXXk | 574000 | 10µM | 680 | 0 | ||
| Rational design/fragment-based screening | 0 | 0 | 0 |
Hits or Leads |
Counter-Screen Assay (Target or Cell Based)enzymatic assay without the enzyme activity on TB growth screened 300 number of hits 57 0 number of leads 0 |