Aerobic Mtb whole cell screens
Last Updated: 2-Nov-2011
Target Description
EC number
|
Genbank accession
|
Rv number
|
Research Investigator(s)
Novartis Institue For Tropical Diseases (NITD), Singapore and Genomics Institute of the Novartis Research Foundation (GNF), USA
Has the target been validated? How?
Validated by:
Chemical |
PubMed References
|
Reagent Description
| Recombinant Protein Name / Gene ID |
Soluble? |
Truncated? |
Mutant? |
PubMed References |
Assay Description
| Assay Name |
Readout |
Format |
PubMed References |
| Cell-based |
|
|
|
Compounds for Screening or Lead Optimization
| Library Name/Indentifier |
Total # of Compounds |
Screened |
HTS Cut Off (ie. 40 um) |
# of Hits |
# of Leads |
PubMed References |
| Novartis archive |
2.2 Million |
|
5uM |
4,800 |
4 +++ |
|
Hits or Leads
|
Counter-Screen Assay (Target or Cell Based)
Cytotox assay |
Narrative Description
SAR, Hit to lead and Target deconvolution is in progress