Dr. Rajiv Shah, Administrator of the United States Agency for International Development (USAID), addressed the importance of investing in innovation and harnessing the power of new global health technologies to achieve widespread impact on those suffering from disease in the most impoverished regions of the world. Dr. Shah’s speech, delivered at the 2010 David E. Barmes Global Health Lecture, highlighted tuberculosis as one of the areas that provide opportunities for realizing transformative health-based successes through the development and introduction of new technologies and tools.