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Clinical Pipeline

Trials for Market Approval Download PPT

Pre-Clinical (GLP)

Sanfetrinem
GlaxoSmithKline, Bill & Melinda Gates Foundation
TBAJ-876 Diarylquinoline
TB Alliance, University of Auckland
S-004992
Shionogi & Co., Ltd
GSK-286
GlaxoSmithKline, TB Drug Accelerator, Bill & Melinda Gates Foundation
TBAJ-587, Diarylquinoline
TB Alliance, University of Auckland, Merck & Co., Inc.
Spectinamide 1810
Microbiotix, Inc.

Phase 1

TBI-223
TB Alliance, Institute of Materia Medica
BTZ-043
University of Munich, Hans-Knöll Institute, Jena, German Center for Infection Research (DZIF)
GSK 3036656
GlaxoSmithKline, European Union Horizon 2020, NIAID, NIH, DHHS
Macozinone (MCZ, PBTZ-169)
iM4TB - Innovative Medicines for Tuberculosis, Bill & Melinda Gates Foundation
SPR720
Spero Therapeutics, LLC
Contezolid (MRX-4/MRX-1)
MicuRx Pharmaceuticals, Inc.
OPC-167832
Otsuka Pharmaceutical Development & Commercialization, Inc.
TBI-166
Institute of Materia Medica, CAMS & PUMC
TBA-7371
TB Alliance
Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371

Phase 2

Telacebec (Q203)
Qurient Co., Ltd, Qurient Co. Ltd. / LLC "Infectex", a portfolio firm of Maxwell Biotech Venture Fund
Q203 Phase 1b Q203-TB-PI-US002
Phase 2 Telacebec (Q203) EBA
Rifampicin
PanACEA, EDCTP, NIAID, NIH, DHHS, USAID
ReDEFINe High-Dose RIF for Meningitis
High-Dose Rifampin
Macozinone (MCZ, PBTZ-169)
Nearmedic Plus LLC
Phase 2a Study of PBTZ169
SQ109
Sequella, Inc
Bedaquiline, Pretomanid, Moxifloxacin, Pyrazidamide (BPaMZ)
TB Alliance
SimpliciTB
Sutezolid
Sequella, Inc, TB Alliance
Delpazolid (LCB01-0371)
LegoChem Biosciences, Inc.
NCT02836483 A Prospective, Randomized, Open, Active-controlled, Interventional, Exploratory, Phase II Trial of LCB01-0371.
TB-PRACTECAL
Médecins Sans Frontières
Auranofin
The Aurum Institute NPC, Calibr, The Scripps Research Institute
TB Host Directed Therapy (TBHDT)
PredictTB
NIAID, NIH, DHHS, Bill & Melinda Gates Foundation, EDCTP
Levofloxacin
CDC TBTC, NIAID, NIH, DHHS, Boston University
TBTC Study 32, Opti-Q
INH, RIF, PZA, MOX
NexGen EBA
Bedaquiline - Delamanid with MBT for MDR
ACTG 5343 Bedaquiline - Delamanid with MBT for MDR
Nitazoxanide
Weill Medical College of Cornell University
Nitzoxanide NZT001 14-day EBA

Phase 3

Nix-TB (B-Pa-L)
TB Alliance
TRUNCATE-TB
University College, London, SPRINT TB (National University of Singapore)
Bedaquiline
Janssen Research & Development, LLC
STREAM Trial Stage 2
SimpliciTB
Delamanid
Otsuka Pharmaceutical Development & Commercialization, Inc.
Delamanid with OBR for MDR TB
Pediatric PK and Safety Trial Delamanid in MDR TB
Rifapentine
CDC TBTC, Sanofi
TBTC Study 31 ACTG 5349 4-month treatment regimens
Bedaquiline - Pretomanid - Linezolid
TB Alliance
Nix-TB (B-Pa-L)
ZeNix (B-Pa-L) NC-007
endTB
Médecins Sans Frontières
Clofazimine
Novartis
Rifampicin
St. George's Hospital University of London
RIFASHORT
Bedaquiline - Linezolid - Levofloxacin with OBR
Bedaquiline - Linezolid with OBR MDR (NExT Trial)
Pretomanid, Moxifloxacin, Pyrazidamide (PaMZ)
TB Alliance
STAND