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Clinical Pipeline

Trials for Market Approval Download PPT

Pre-Clinical (GLP)

Sanfetrinem
GlaxoSmithKline, Bill & Melinda Gates Foundation
TBAJ-876 Diarylquinoline
TB Alliance, University of Auckland
S-004992
Shionogi & Co., Ltd
GSK-286
GlaxoSmithKline, TB Drug Accelerator, Bill & Melinda Gates Foundation
TBAJ-587, Diarylquinoline
TB Alliance, University of Auckland, Merck & Co., Inc.
Spectinamide 1810
Microbiotix, Inc.

Phase 1

TBI-223
TB Alliance, Institute of Materia Medica
SPR720
Spero Therapeutics, LLC, Bill & Melinda Gates Medical Research Institute
Phase 1 Safety, Tolerability, and Pharmacokinetics of SPR720
BTZ-043
University of Munich, Hans-Knöll Institute, Jena, German Center for Infection Research (DZIF), European and Developing Countries Clinical Trials Partnership (EDCTP), Radboud University
BTZ-043 Multiple Ascending Dose / EBA
Phase 1 Safety, Tolerability, and Pharmacokinetics of SPR720
Spero Therapeutics, LLC
TBA-7371
TB Alliance, Bill & Melinda Gates Medical Research Institute, Foundation for Neglected Disease Research
Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371
Macozinone (MCZ, PBTZ-169)
iM4TB - Innovative Medicines for Tuberculosis, Bill & Melinda Gates Foundation
OPC-167832
Otsuka Pharmaceutical Development & Commercialization, Inc.
OPC-167832 Phase 1 / 2 EBA
TBI-166
Institute of Materia Medica, CAMS & PUMC

Phase 2

Telacebec (Q203)
Qurient Co., Ltd, Qurient Co. Ltd. / LLC "Infectex", a portfolio firm of Maxwell Biotech Venture Fund
Q203 Phase 1b Q203-TB-PI-US002
Phase 2 Telacebec (Q203) EBA
Rifampicin
PanACEA, EDCTP, NIAID, NIH, DHHS, USAID
ReDEFINe High-Dose RIF for Meningitis
High-Dose Rifampin
Macozinone (MCZ, PBTZ-169)
Nearmedic Plus LLC
Phase 2a Study of PBTZ169
GSK 3036656
GlaxoSmithKline, European Union Horizon 2020, NIAID, NIH, DHHS
Bedaquiline, Pretomanid, Moxifloxacin, Pyrazidamide (BPaMZ)
TB Alliance
SimpliciTB
SQ109
Sequella, Inc
Sutezolid
Sequella, Inc, TB Alliance
Delpazolid (LCB01-0371)
LegoChem Biosciences, Inc.
NCT02836483 A Prospective, Randomized, Open, Active-controlled, Interventional, Exploratory, Phase II Trial of LCB01-0371.
TB-PRACTECAL
Médecins Sans Frontières
Auranofin
The Aurum Institute NPC, Calibr, The Scripps Research Institute
TB Host Directed Therapy (TBHDT)
PredictTB
NIAID, NIH, DHHS, Bill & Melinda Gates Foundation, EDCTP
Levofloxacin
CDC TBTC, NIAID, NIH, DHHS, Boston University
TBTC Study 32, Opti-Q
INH, RIF, PZA, MOX
NexGen EBA
Bedaquiline - Delamanid with MBT for MDR
ACTG 5343 Bedaquiline - Delamanid with MBT for MDR
Nitazoxanide
Weill Medical College of Cornell University
Nitzoxanide NZT001 14-day EBA