TB Alliance, Bill & Melinda Gates Medical Research Institute, Foundation for Neglected Disease Research
Chemical Class:

AZ 7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1) with an IC50 value of 10 nM.1 It also inhibits PDE6 with an IC50 value of 4 µM.1 AZ 7371 has been shown to be active against M. tuberculosis with an MIC range of 0.78-3.12 µM and demonstrates efficacy in a rodent model of tuberculosis.

The TB Alliance has begun a Phase 1, Partially-Blind, Placebo Controlled, Randomized, Combined Single Ascending Dose With a Food Effect Cohort and Multiple Ascending Dose and a Drug-Drug Interaction Study to Evaluate the Safety, Tolerability, Pharmacokinetics and the Pharmacokinetic Interaction Between TBA-7371 With Midazolam and Bupropion in Healthy Adult Subjects