Compound

Sutezolid

Sequella, Inc, TB Alliance
Names
PNU-100480
Chemical Class:
Oxazolidinone
Name of Target:
Protein Synthesis. Binds the bacterial 23S rRNA of the 50S subunit and prevents the formation of a functional 70S initiation complex.
Description
Standard multiple ascending dose Phase I study evaluating PK and safety. 14 day dose-escalation complete; 28 day study in healthy volunteers also completed May 2010. PNU-100480 is being developed for the treatment of both drug resistant and sensitive tuberculosis. This is an efficacy and safety study to characterize the effect of PNU-100480 when given for 14 days to treatment-naive patients with drug-sensitive pulmonary tuberculosis.
Trial Associations
Developer Associations