Inhibitors of DosRST signaling and persistence

Michigan State University
RB Abramovitch
Chemical Class:
Name of Target:

The Mycobacterium tuberculosis DosRST two-component regulatory system promotes survival during non-replicating persistence.

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Zheng H, Colvin CJ, Johnson BK, Kirchhoff PD, Wilson M, Jorgensen-Muga K, Larsen SD, Abramovitch RB. Nat Chem Biol. 2017 Feb;13(2):218-225. doi: 10.1038/nchembio.2259. Epub 2016 Dec 19. PMID: 27992879

Three inhibitors have been identified: artemisinin, HC102A, and HC103A.

Presented at the ASM Conference on Tuberculosis: Past, Present and Future. April 4, 2017.  Abstract S5:2


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