JSF-3285

JSF-3285 is an indazole targeting KasA (beta-ketoacylsynthase) published in 2020 by Rutgers University.  JSF-3285 is a small molecule with potentcy in vitro and in vivo in mouse models of infection. It shows activitiy against DS, MDR, and XDR TB strains. KasA is a novel mechanism of action amongst current TB drugs. 

http://rutgers.technologypublisher.com/tech?title=JSF-3285%2C_A_Novel_KasA_Inhibitor_for_Tuberculosis