Similar to PBTZ-169. MIC reported as 0.15 ug/ml. Active in vivo, orally bioavailable, 12.5 mg/kg
From: 126.com <lmllyx@126.com>
Sent: Monday, October 11, 2021 3:08 AM
To: Laughon, Barbara (NIH/NIAID) [E] <BLAUGHON@niaid.nih.gov>
Subject: Re:TZY-5-84
Dear Prof. Barbara E. Laughon,
Nice to hear from you.
Thanks very much for adding our compound TZY-5-84 to last year’s pipeline. TZY-5-84 does not go to GLP toxicology testing at present. We have been negotiating with CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. Ltd (http://www.e-cspc.com/) about the further development of TZY-5-84. Hopefully, we together will accelerate the advancement of TZY-5-84 in the next two years.
Best regards,
Mingliang Liu
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College.
No 1, Tiantan Xili, Beijing 100050, P.R.China
Tel. / Fax: +86-10-63036965