Chemical Class:
Piperazine benzothiazinone

Similar to PBTZ-169.  MIC reported as 0.15 ug/ml.  Active in vivo, orally bioavailable, 12.5 mg/kg

From: <>
Sent: Monday, October 11, 2021 3:08 AM
To: Laughon, Barbara (NIH/NIAID) [E] <>
Subject: Re:TZY-5-84

Dear Prof. Barbara E. Laughon,

        Nice to hear from you. 

        Thanks very much for adding our compound TZY-5-84 to last year’s pipeline. TZY-5-84 does not go to GLP toxicology testing at present. We have been negotiating with CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. Ltd ( about the further development of TZY-5-84.  Hopefully, we together will accelerate the advancement of TZY-5-84 in the next two years. 

         Best regards,

Mingliang Liu

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College.

No 1, Tiantan Xili, Beijing 100050, P.R.China

Tel. / Fax: +86-10-63036965