News about 'Front Lines of TB R&D'

[wpaudio url=”/blog/media/podcasts/Anne_Lenaerts_Interview_edited-norm.mp3″ text=”Anne Lenaerts Interview” dl=”0″] Summary: Dr. Anne Lenaerts is an associate professor at Colorado State University”s College of Veterinary Medicine and Biomedical Sciences in the Department of Microbiology, Immunology...

The Bill & Melinda Gates Foundation is now accepting letters of inquiry for the new grant program Biomarkers for the Diagnosis of Tuberculosis. This grant program is part of the Grand Challenges in Global Health initiative. With up to $12 million of funding, the program seeks to validate...

Chemical Structure of Pyrazinamide Ahmad Z, Fraig MM, Bisson GP, Nuermberger EL, Grosset JH, Karakousis PC. Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis. Antimicrob Agents Chemother. 2011 Jan 31. [Epub ahead of print] First discovered as...

Gupta A, Bhosale R, Kinikar A, Gupte N, Bharadwaj R, Kagal A, Joshi S, Khandekar M, Karmarkar A, Kulkarni V, Sastry J, Mave V, Suryavanshi N, Thakar M, Kulkarni S, Tripathy S, Sambarey P, Patil S, Paranjape R, Bollinger RC, Jamkar A; Six Week Extended-Dose Nevirapine (SWEN) India Study Team...

Aagaard C, Hoang T, Dietrich J, Cardona PJ, Izzo A, Dolganov G, Schoolnik GK, Cassidy JP, Billeskov R, Andersen P. A multistage tuberculosis vaccine that confers efficient protection before and after exposure. Nat Med. 2011 Jan 23. [Epub ahead of print] Claus Aagaard, et al., presented a series of...

Saunders NJ, Urmi HT, Thomson ML, Doig C, Laurenson IF, Blaxter ML. Stepwise mutation to multiple drug resistance in Mycobacterium tuberculosis in an otherwise stable genetic backgrounddoes not support models of high mutation in the host and emphasizes the need for maintained effective...

Ahmad Z, Peloquin CA, Singh RP, Derendorf H, Tyagi S, Ginsberg A, Grosset JH, Nuermberger EL. PA-824 exhibits time-dependent activity in a murine model of tuberculosis. Antimicrob Agents Chemother. 2011 Jan;55(1):239-45. Epub 2010 Oct 11.PMID: 20937781 [PubMed – in process] Researchers testing the...

New Evidence Showing Patients with TB Have an Increased Risk of Lung Cancer Yu, et al, in China conducted a population-based cohort study to better understand the relationship between tuberculosis (TB) and lung cancer. Analysis of patient care data from the National Health Insurance (NHI) program...

ELIMINATING TB BY 2050: AN ACCELERATED GLOBAL RESEARCH STRATEGY PLEASE PARTICIPATE TO HELP TB RESEARCH MOVING FORWARD As a member of the large TB community, you might well be aware of the fact that research is essential for speeding up progress towards Tuberculosis (TB) elimination by 2050. We need...

Raghuvanshi S, Sharma P, Singh S, Van Kaer L, Das G. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proc Natl Acad Sci U S A. 2010 Dec 6. [Epub ahead of print] On the early drug discovery front, this study may provide researchers additional areas to target for...

New TB/HIV Working Group Report: Priority Research Questions for TB&HIV in HIV-Prevalent and Resource-Limited Settings TB-HIV Report Nov 2010 In November 2008, the Global TB/HIV Working Group of the Stop TB Partnership , in collaboration with the WHO Stop TB and HIV/AIDS departments and the...

2010 Annual Meeting Following the guest speakers ( click here to view that recap ), several representatives from companies conducting clinical trials of TB drug candidates presented brief updates on progress made in the clinical development of their candidates. Click the presentation name to...

2010 Annual Meeting Co-chairs of WGND, Mel Spigelmen and Bill Bishai opened the annual meeting by welcoming the attendees and briefly reviewing the agenda for the meeting. There were several guest speakers that presented on various topics including the website, community engagement, open source...

Photos from our 2010 Annual Meeting on November 12 in Berlin, Germany. To view the meeting recaps, please visit: 2010 Annual Meeting Speakers Recap 2010 Annual Meeting Panel Presentations and Audience Q&A class="ngg-galleryoverview ngg-ajax-pagination-none" id="ngg-gallery-...

a sputum cup This is part 3 of Lisan Parker’s photo collection from her recent trip to South Africa as part of her new role as Research Liason to the KwaZulu-Natal Research Institute for Tuberculosis and HIV ( click here to view part 1 or click here to view part 2 ). These pictures are the last set...