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Otsuka's Novel DprE1 Inhibitor Shows Promising Anti-Tuberculosis Activity

On May 21st, Antimicrbial Agents and Chemotherapy published an article on Otsuka's novel anti-tuberculosis compound, OPC-167832. This molecule, a DprE1 inhibitor, demonstrated potent bactericidal activity and exhibited significant combination effects in 2-drug combinations with delamanid, bedaquiline, or levofloxacin. Additionally, 3- or 4- drug regimens comprising of delamanid and OPC-167832 as the core along with bedaquiline, moxifloxacin, or linezolid showed efficacy in reducing the bacterial burden and preventing relapse superior to that of the standard treatment regimen. 

To read the full article Antimicrobial Agents and Chemotherapy article, please click here: OPC-167832, a Novel Carbostyril Derivative with Potent Antituberculosis Activity as a DprE1 Inhibitor

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