News

Spero Therapeutics Receives Grant from NIH for SPR720

Spero Therapeutics Receives Grant from National Institutes of Health to Explore Novel Treatment Combinations for Tuberculosis

CAMBRIDGE, Mass., May 4, 2017—Spero Therapeutics, LLC, a biopharmaceutical company founded to develop novel therapies for the treatment of bacterial infections, today announced that it has received a grant from the National Institutes of Health (NIH) to conduct additional preclinical studies of SPR720, the Company’s novel oral bacterial gyrase inhibitor, for the treatment of tuberculosis (TB). The non-dilutive grant of $564,718 is part of the NIH’s Small Business Innovation Research (SBIR) program (Grant Number: 1R44AI131749-01).

As part of this research program, Spero will collaborate with the Central New York Research Corporation to assess the safety and efficacy of SPR720 in combination with rifampin and other existing standard-of-care drugs in preclinical models of both drug-susceptible TB and multidrug resistant (MDR) TB. The goal of the research is to assess novel combinations that could potentially shorten the duration of treatment and identify new drug combinations that would be effective against MDR TB.

“We are pleased with the progress we have made in characterizing the utility of SPR720 in non-tuberculous mycobacteria since acquiring the compound last year and we are excited to expand our research to TB,” said Ankit Mahadevia, M.D., Chief Executive Officer of Spero. “Our strategy is focused on discovering, developing and commercializing antibiotics in areas of unmet need. Like NTM, TB has high rates of mortality and current treatment options are becoming less effective as the rate of multidrug resistance continues to grow.”

Read full press release here

More News
30 Mar 2021
Médecins Sans Frontières (MSF) published a press release on World TB Day 2021 announcing their clinical trial, TB-Practecal , investigating novel treatment for MDR-TB has stopped enrolling earlier than originally planned due to promising results. The trial's independent data safety and monitoring...
3 Feb 2021
Last week, the World Health Organization (WHO) held a consultation to discuss the definition of extensively drug resistant (XDR) tuberculosis. The meeting was held to discuss novel treatment regimens and diagnostics for drug-resistant TB and determine its impact on the definition of XDR-TB. The...
10 Dec 2020
The Stop TB Partnership Working Group on New TB Vaccines (WGNV), Working Group on New TB Drugs (WGND), and New Diagnostics Working Group (NDWG) are developing an online course specifically designed for advocates and affected communities to provide a base of knowledge in TB research and to generate...