News about 'r&d'

2010 Annual Meeting Co-chairs of WGND, Mel Spigelmen and Bill Bishai opened the annual meeting by welcoming the attendees and briefly reviewing the agenda for the meeting. There were several guest speakers that presented on various topics including the website, community engagement, open source...

NC001 Today, the TB Alliance announced the first clinical trial to test multiple new TB drugs in combination; the trial is known as New Combination 1 (NC001).The experimental regimen undergoing testing in this trial consists of experimental TB drugs PA-824, Moxifloxacin, and Pyrazinamide, an...

Working Group on New TB Drugs Annual Meeting The 2010 Annual Meeting will be held on November 12, 2010 Please check this page for continuously updated information. The WGND will host our annual meeting prior to the start of the 41st Union World Conference on Lung Health (The Union) in Berlin. WHEN...

Dear readers, please accept our apologies for missing the past couple of Tuesday R&D posts on the latest developments and meetings taking place in the TB R&D arena. There have been several important changes afoot and we are in the process of hammering out the final details so things will be...

The following is a guest posting from Joanna Breitstein of the TB Alliance, reporting from the Open Forum 4 in Addis Ababa, Ethiopia. Open Forum 4 While there were few new TB treatment prospects a few years ago, today there are 10 drugs in the global development pipeline. Noting the sea of change,...

A distinct whole-blood 86-gene transcriptional signature of active TB (Figure 2 in the paper) Last week, a paper was published in Nature by Matthew Berry, Christine Graham et al. which received a fair amount of notice. The authors presented data identifying a probable TB gene signature in people...

Review of JACS Communication, “Catalytic Asymmetric Synthesis of R207910″ By Christopher Cooper, Director of Chemistry, TB Alliance Retrosynthetic Approach to TMC207 (click to view larger) The novel antitubercular agent TMC207 ( Tibotec , a Johnson & Johnson company) represents an impressive...

This article originally appeared on Citizen News Service. Click here to read the original post. by Shobha Shukla Open Forum 4 The Open Forum 4 on key issues in tuberculosis (TB) drug development is all set to begin in Addis Ababa, Ethiopia (18-19 August 2010). This Open Forum 4, will raise and...

2.1 Å DNA gyrase complex with GSK299423 (Figure 2 from paper) This week we reposted an article from DailyFinance.com regarding a new antibactierial compound from GlaxoSmithKline (GSK) . GSK has recently published a Nature paper describing the 2.1 angstom crystal structure of Staphylococcus aureus...

Cofactor F420 Structure The need for the identification of novel TB drug targets and biomarkers has been highlighted in a few of our posts over the last several months. A recent epublication (online manuscript before print) in the Journal of Bacteriology by Jeremy D. Selengut and Daniel H. Haft...

Cepheid® MTB/RIF Assay cartridge In our latest ‘Sanatorium Files’ post ‘Diagnosis Dilemma’ , we commented on the current advances in TB diagnostics. We’re following up on this theme for the next couple of posts to share the scientific data supporting some of the most promising of these new...

A biochip assay- an example of a diagnostic test based on disease biomarkers By far, one of the greatest needs in TB R&D is the identification of biomarkers. The value of biomarkers cannot be overemphasized. Briefly, we will highlight what biomarkers are, how they are used, and describe their...

Johns Hopkins Medicine On Friday, June 11 th , the Johns Hopkins University Center for Tuberculosis Research hosted their annual scientific meeting and the WGND was there to cover the event. Approximately 100-200 people were present including persons from NIH and small pharmaceutical companies...

The TB Pipeline starts here! Our goal is to keep our audience up to date on the latest TB drug research & development. The past couple of months have seen a flurry of publishing activity. In order to present these to you quickly, we are diverging from our usual one-by-one analysis in favor of...

credit: Mary O'Reilly Science Illustration By Gerry Waters, Senior Director, Biology at the TB Alliance A team of researchers led by Rainer Kalscheuer and Bill Jacobs at the Albert Einstein College of Medicine in New York recently published a paper titled “Self-poisoning of M. tuberculosis by...