News about 'r&d'

Zebrafish as TB animal model When studying an infection it’s important to have access to a model for examining the progression of disease. In tuberculosis research, such model systems range from mice to guinea pigs to primates, with many species in between. Lalita Ramakrishnan has spent much of her...

autophagy by any other name... The WGND blog is in the R&D vanguard! Recently, Nick Be wrote a post highlighting the activation of the cellular ‘self-eating’ mechanism known as autophagy in the elimination of TB from an infected individual. On March 5, 2010, Cell published a paper by Kumar and...

Detailed view of the ligand-binding site of EthR co-crystallized with BDM31381 (EthRInhibitor) Developing new TB drugs is inhibited by so many factors – namely: The flow through the TB drug pipeline is slow at best. Despite decades of hard work, we still use the demanding regimen developed 50 years...

source: http://www.glsynthesis.com/drug-discovery.html Drug discovery teams around the world have been actively selecting targets that are likely to be important in killing dormant or very slowly replicating tuberculosis in an effort to shorten the time to cure; for drug sensitive TB, six to nine...

This week we highlight two recent papers in TB R&D – TB and HIV treatment and PA-824. Tuberculosis is the leading cause of the death in HIV positive individuals in the developing world. Major challenges exist in treating both diseases simultaneously as drug-drug interactions are common between...

This interview originally appeared on Planeta Salud’s website . Pere Joan Cardona For 15 years, Dr. Cardona has focused his studies on infection with Mycobacterium tuberculosis (Mtb) has developed a hypothesis and dynamics of tuberculosis infection, which could explain why the Koch bacillus...

Welcome to the weekly TB R&D news highlights series! The goal of the WGND blog as highlighted during our launch is to stimulate global conversation pertaining to TB research and development. In order to further discussion, every Tuesday we will attempt to highlight selected stories in TB drug...