The 2017 Conference on Tuberculosis Drug Discovery and Development will explore the entire process of drug discovery from clinical development of new drugs for tuberculosis (TB) to the underlying biology of Mycobacterium tuberculosis that impacts drug discovery efforts. The conference will address the unique challenges in TB drug discovery through discussion of clinical trial design, complimentary approaches to identification of lead compounds, vulnerable targets and pathways, host-directed therapies, and non-traditional approaches to TB prevention and treatment.