MBX-4888A

Submitted by barbara on

Using structure-based design, a new semisynthetic series of spectinomycin analogs with selective ribosomal inhibition and narrow-spectrum antitubercular activity had been generated. In multiple murine infection models, these spectinamides were well tolerated, significantly reduced lung mycobacterial burden and increased survival. In vitro studies demonstrated a lack of cross resistance with existing tuberculosis therapeutics, activity against multidrug-resistant (MDR) and extensively drug-resistant tuberculosis and an excellent pharmacological profile.

ECCMID - European Congress of Microbiology and Infectious Diseases

Submitted by barbara on

http://www.eccmid.org/

The world’s leading experts will come together to discuss the latest developments in infectious diseases, infection control and clinical microbiology. The congress committee is preparing a comprehensive scientific programme with keynote lectures, symposia, educational and oral sessions on parallel tracks. We look forward to seeing you along with thousands of your colleagues from around the globe in Vienna.

Rutgers Researchers Determine the 3D Structure of Drug Target for Rifampin

Scientist at Rutgers University and their collaborators have published an article in Molecular Cell illustrating the three-dimensional structure of the drug target for the drug rifampicin. The abstract for the article is below. 

TITLE: Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition

AUTHOR: Lin, Wei et al.

Inhibitors of DosRST signaling and persistence

Submitted by barbara on

The Mycobacterium tuberculosis DosRST two-component regulatory system promotes survival during non-replicating persistence.

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Zheng H, Colvin CJ, Johnson BK, Kirchhoff PD, Wilson M, Jorgensen-Muga K, Larsen SD, Abramovitch RB. Nat Chem Biol. 2017 Feb;13(2):218-225. doi: 10.1038/nchembio.2259. Epub 2016 Dec 19. PMID: 27992879

Pages

Subscribe to Working Group for New TB Drugs RSS