News

TB R&D Update: New treatment strategy using Bedaquiline in combination with heart medication, Verapamil

Researchers at the Center for Tuberculosis Research located at Johns Hopkins University School of Medicine have shown that heart medication, verapamil administered in combination with bedaquline lowers the toxicity of the TB drug without altering its efficacy. The paper, titled β€˜Verapamil Increases the Bactericidal Activity of Bedaquiline Against Mycobacterium tuberculosis in the Mouse Modelβ€˜ was recently published in Antimicrobial Agents and Chemotherapy.

Although Bedaquiline is an effective anti-tuberculosis agent, it has significant liver and heart toxicity. Supplementing bedaquiline treatment in mice models with verapamil reduced not only the dosage required and thus toxicity, but also the emergence of antibiotic resistance, without sacrificing potency.

Scientists at the Tuberculosis Research Center plan to use this new data to design clinical trials.

Related Links

β€˜Verapamil Increases the Bactericidal Activity of Bedaquiline Against Mycobacterium tuberculosis in the Mouse Model

Study indicates new strategy to treat tuberculosis

New treatment strategy allows lower doses of toxic tuberculosis drug without compromising potency

Additional Links

Sirturo approved for conditional use in European Union to treat MDR-TB in adults

Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis

More News
17 Sep 2019
Earlier this month, the NIH announced two new Funding Opportunity Annoucnements (FOAs) on the topic of Myeloid-Derived Suppressor Cells (MDSC) as potential therapeutic targets in TB/HIV co-infected patients. The purpose of these FOAs is to invite applications for support of innovative clinical,...
14 Aug 2019
FDA released the following press release on Wednesday, August 14th: The U.S. Food and Drug Administration today approved Pretomanid Tablets in combination with bedaquiline and linezolid for the treatment of a specific type of highly treatment-resistant tuberculosis (TB) of the lungs. β€œThe threat of...
27 Jun 2019
-- Globe Newswire reported on June 20th -- Spero Therapeutics, Inc. , a multi-asset clinical-stage biopharmaceutical company focused on identifying, developing and commercializing treatments in high unmet need areas involving multi-drug resistant (MDR) bacterial infections and rare diseases, today...