News about 'publications'

Botella H, Peyron P, Levillain F, Poincloux R, Poquet Y, Brandli I, Wang C, Tailleux L, Tilleul S, Charrière GM, Waddell SJ, Foti M, Lugo-Villarino G, Gao Q, Maridonneau-Parini I, Butcher PD, Castagnoli PR, Gicquel B, de Chastellier C, Neyrolles O. Mycobacterial p(1)-type ATPases mediate resistance...

Yesterday, BBC News published an article on the WHO Plan entitled “Consolidated action plan to prevent and combat multidrug- and extensively drug-resistant tuberculosis in the WHO European Region 2011–2015.” The plan outlines the problem as well as a solution that could save 120,000 lives if...

Last week we posted information about two special issues of Future Medicinal Chemistry focused on neglected diseases. Future Medicinal Chemistry (September 2011, Volume 3, Number 11) have a few articles on tuberculosis drug development: Diarylquinolines, synthesis pathways and quantitative...

Over the last week, some announcements have been released concerning new tools, publications and meeting materials that may be of value to the TB community including materials from the WGND sponsored “Essentiality of Pyrazinamide” Workshop, an interactive map of clinical trials from PACTR , and a...

Special Focus: Neglected Diseases [PART 1]. Future Medicinal Chemistry. August 2011, Volume 3, Number 10 ( free issue ) Special Focus: Neglected Diseases [PART 2]. Future Medicinal Chemistry. September 2011, Volume 3, Number 11 (not yet released) The August and September issues of Future Medicinal...

pyrazinamide (PZA) Shi W, Zhang X, Jiang X, Yuan H, Lee JS, Barry CE 3rd, Wang H, Zhang W, Zhang Y. Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis . Science. 2011 Aug 11. [Epub ahead of print] This week we highlight an article published out of Ying Zhang’s laboratory at Johns...

The WHO issued updated guidelines on the programmatic management of drug-resistant TB on August 4, 2011 online in the European Respiratory Journal . Abstract The production of guidelines for the management of drug-resistant tuberculosis fits the mandate of the World Health Organization (WHO) to...

Click here for full report The United Nations (UN) released a report on July 12 on the progress made thus far on the 8 Millennium Development Goals (MDGs). The eight MDGs include: end poverty and hunger, universal education, gender equality, child health, maternal health, combat HIV/AIDS,...

Silva RF, Mendonc SCM, Carvalho LM, Reis AM, Gordo I, Trindade S, Dionisio F. Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations. PLoS Genetics. 2011 July;7(7):1-10. This week we have an article by researchers from Portugal that suggests that in the case...

Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR Jr. Novel Inhibitors of InhA Efficiently Kill Mycobacterium tuberculosis under Aerobic and Anaerobic Conditions. Antimicrob Agents Chemother. 2011 Aug;55(8):3889-98. Epub 2011 May 31...

BiBianco MV , Blanco FC, Imperiale B, Forrellad MA , Rocha RV, Klepp LI , Cataldi AA , Morcillo N, Bigi F. Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds. BMC Infectious Diseases. 2011 Jul 16; 11:195. [Epub ahead of print] This week, we present an...

Click here for full report A report entitled “An Evaluation of Drug-resistant TB Treatment Scale-up” was issued by the Médecins Sans Frontières (MSF), Partners in Health (PIH), and Treatment Action Group (TAG) on 7 July, 2011 and looks at the factors contributing to the slow progress of efforts to...

Diacon AH, Dawson R, Hanekom M, Narunsky K, Venter A, Hittel N, Geiter LJ, Wells CD, Paccaly AJ, Donald PR. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int J Tuberc Lung Dis . 2011 Jul; 15 ( 7 ):949-54. This week, we review a recent...

A Dowsett, Health Protection Agency/Science Photo Library Vento S, Lanzafame M. Tuberculosis and cancer: a complex and dangerous liaison. Lancet Oncol. 2011 Jun;12(6):520-2. This week we review a commentary on the correlations between tuberculosis and cancer, specifically lung cancer. There are...

Kevin DA, Meujo DAF, Hamann MT. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites. Expert Opinion on Drug Discovery 2009 Feb;4(2):109-146(38). doi:10.1517/17460440802661443. During this week’s TB R&D Weekly...