News about 'drug discovery'

1 Nov 2011
2011 WGND Annual Meeting (Lille, France) During last week, the Stop TB Partnership Working Group on New Drugs had a successful annual meeting in Lille, France, in conjunction with the 42nd Union World Conference . There were several updates to the Global TB Drugs Pipeline showing progress toward...
4 Oct 2011
Dr. Sanjib Bhakta Summary: This week’s interview is with Dr. Sanjib Bhakta who is a Senior Lecturer in Microbiology at Birkbeck, University of London. In the interview, we discuss his work in screening for potential candidates for anti-tuberculosis treatment. Dr. Bhakta’s Laboratory has developed...
28 Sep 2011
On September 16, the 4th International Workshop on Clinical Pharmacology of Tuberculosis Drugs was held adjacent to the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) which was held from September 17 to 19. Between the two meetings, there were many updates related to TB...
19 Sep 2011
Botella H, Peyron P, Levillain F, Poincloux R, Poquet Y, Brandli I, Wang C, Tailleux L, Tilleul S, Charrière GM, Waddell SJ, Foti M, Lugo-Villarino G, Gao Q, Maridonneau-Parini I, Butcher PD, Castagnoli PR, Gicquel B, de Chastellier C, Neyrolles O. Mycobacterial p(1)-type ATPases mediate resistance...
12 Sep 2011
We invite you to join us for the Stop TB Partnership Working Group on New Drugs’ Annual Meeting 2011 at the Grand Palais in Lille, France, on October 26. Also, we are sponsoring a dinner on October 25 at Le Barbue d’Anvers in Lille to allow our Sub-groups (Biology/Targets, Candidates, Critical...
7 Sep 2011
Last week we posted information about two special issues of Future Medicinal Chemistry focused on neglected diseases. Future Medicinal Chemistry (September 2011, Volume 3, Number 11) have a few articles on tuberculosis drug development: Diarylquinolines, synthesis pathways and quantitative...
29 Aug 2011
Special Focus: Neglected Diseases [PART 1]. Future Medicinal Chemistry. August 2011, Volume 3, Number 10 ( free issue ) Special Focus: Neglected Diseases [PART 2]. Future Medicinal Chemistry. September 2011, Volume 3, Number 11 (not yet released) The August and September issues of Future Medicinal...
15 Aug 2011
pyrazinamide (PZA) Shi W, Zhang X, Jiang X, Yuan H, Lee JS, Barry CE 3rd, Wang H, Zhang W, Zhang Y. Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis . Science. 2011 Aug 11. [Epub ahead of print] This week we highlight an article published out of Ying Zhang’s laboratory at Johns...
1 Aug 2011
Silva RF, Mendonc SCM, Carvalho LM, Reis AM, Gordo I, Trindade S, Dionisio F. Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations. PLoS Genetics. 2011 July;7(7):1-10. This week we have an article by researchers from Portugal that suggests that in the case...
25 Jul 2011
Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR Jr. Novel Inhibitors of InhA Efficiently Kill Mycobacterium tuberculosis under Aerobic and Anaerobic Conditions. Antimicrob Agents Chemother. 2011 Aug;55(8):3889-98. Epub 2011 May 31...
18 Jul 2011
BiBianco MV , Blanco FC, Imperiale B, Forrellad MA , Rocha RV, Klepp LI , Cataldi AA , Morcillo N, Bigi F. Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds. BMC Infectious Diseases. 2011 Jul 16; 11:195. [Epub ahead of print] This week, we present an...
11 Jul 2011
Diacon AH, Dawson R, Hanekom M, Narunsky K, Venter A, Hittel N, Geiter LJ, Wells CD, Paccaly AJ, Donald PR. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int J Tuberc Lung Dis . 2011 Jul; 15 ( 7 ):949-54. This week, we review a recent...
20 Jun 2011
Kevin DA, Meujo DAF, Hamann MT. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites. Expert Opinion on Drug Discovery 2009 Feb;4(2):109-146(38). doi:10.1517/17460440802661443. During this week’s TB R&D Weekly...
25 Apr 2011
Paul Elkington, Takayuki Shiomi, Ronan Breen, Robert K. Nuttall, Cesar Augusto Ugarte-Gil, Naomi F. Walker, Luísa Saraiva, Bernadette Pedersen, Francesco Mauri, Marc Lipman, Dylan R. Edwards, Brian D. Robertson, Jeanine D’Armiento and Jon S. Friedland. MMP-1 drives immunopathology in human...
28 Mar 2011
The New York Academy of Sciences will be hosting a symposium entitled “New Frontiers in Marine Drug Discovery” on May 20, 2011. This 1-day symposium will overview the current state of the art in Marine Biomedicine and its role in the context of the drug discovery process – from the perspectives of...

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