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For World TB Day 2024, the WGND is spotlighting a monumental achievement in TB drug research and development: the Global TB Drug Pipeline has never been bigger than it is today. The number of drug candidates being clinically evaluated for use in the treatment of adult pulmonary TB has surpassed that of all previous years. The WGND is tracking 19 drug candidates that have initiated or completed a Phase 1 clinical trial for use in treating Tuberculosis. Most have been or are currently being evaluated in a Phase 2 clinical trial and one has made it to Phase 3. These 19 do...
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29 Aug 2011
Special Focus: Neglected Diseases [PART 1]. Future Medicinal Chemistry. August 2011, Volume 3, Number 10 ( free issue ) Special Focus: Neglected Diseases [PART 2]. Future Medicinal Chemistry. September 2011, Volume 3, Number 11 (not yet released) The August and September issues of Future Medicinal...
17 Aug 2011
The Stop TB Partnership has provided information and references to help partners to prepare a successful proposal to The Global Fund to Fight HIV/AIDS, Tuberculosis, and Malaria . The call for Round 11 applications was released on August 15. Go to http://www.stoptb.org/global/tbfriends/ to get more...
15 Aug 2011
pyrazinamide (PZA) Shi W, Zhang X, Jiang X, Yuan H, Lee JS, Barry CE 3rd, Wang H, Zhang W, Zhang Y. Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis . Science. 2011 Aug 11. [Epub ahead of print] This week we highlight an article published out of Ying Zhang’s laboratory at Johns...
10 Aug 2011
The WHO issued updated guidelines on the programmatic management of drug-resistant TB on August 4, 2011 online in the European Respiratory Journal . Abstract The production of guidelines for the management of drug-resistant tuberculosis fits the mandate of the World Health Organization (WHO) to...
3 Aug 2011
Click here for full report The United Nations (UN) released a report on July 12 on the progress made thus far on the 8 Millennium Development Goals (MDGs). The eight MDGs include: end poverty and hunger, universal education, gender equality, child health, maternal health, combat HIV/AIDS,...
1 Aug 2011
Silva RF, Mendonc SCM, Carvalho LM, Reis AM, Gordo I, Trindade S, Dionisio F. Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations. PLoS Genetics. 2011 July;7(7):1-10. This week we have an article by researchers from Portugal that suggests that in the case...
26 Jul 2011
Recent articles from around the globe related to governments addressing problems with providing treatment services to those with tuberculosis: A Day in the Life of a TB Worker When Farhad Jameel, case manager at Gwinnett County’s tuberculosis control clinic, arrives at work each morning, he...
25 Jul 2011
Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR Jr. Novel Inhibitors of InhA Efficiently Kill Mycobacterium tuberculosis under Aerobic and Anaerobic Conditions. Antimicrob Agents Chemother. 2011 Aug;55(8):3889-98. Epub 2011 May 31...
20 Jul 2011
Mike Mandelbaum is Chief Executive of TB Alert, which is the UK’s National and International Tuberculosis charity – the only British charity working solely on fighting TB in the UK and overseas. TB Alert is a young charity, registered in late 1998 and launched at the Houses of Parliament on World...
18 Jul 2011
BiBianco MV , Blanco FC, Imperiale B, Forrellad MA , Rocha RV, Klepp LI , Cataldi AA , Morcillo N, Bigi F. Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds. BMC Infectious Diseases. 2011 Jul 16; 11:195. [Epub ahead of print] This week, we present an...
13 Jul 2011
Click here for full report A report entitled “An Evaluation of Drug-resistant TB Treatment Scale-up” was issued by the Médecins Sans Frontières (MSF), Partners in Health (PIH), and Treatment Action Group (TAG) on 7 July, 2011 and looks at the factors contributing to the slow progress of efforts to...
11 Jul 2011
Diacon AH, Dawson R, Hanekom M, Narunsky K, Venter A, Hittel N, Geiter LJ, Wells CD, Paccaly AJ, Donald PR. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int J Tuberc Lung Dis . 2011 Jul; 15 ( 7 ):949-54. This week, we review a recent...
6 Jul 2011
In the July 7 issue of the New England Journal, two articles and an editorial on latent TB and TB prevention are included: Articles Martinson NA, et al “New regimens to prevent tuberculosis in adults with HIV infection” N Engl J Med 2011; 365: 11-20. Madhi SA, et al “Primary isoniazid prophylaxis...
27 Jun 2011
A Dowsett, Health Protection Agency/Science Photo Library Vento S, Lanzafame M. Tuberculosis and cancer: a complex and dangerous liaison. Lancet Oncol. 2011 Jun;12(6):520-2. This week we review a commentary on the correlations between tuberculosis and cancer, specifically lung cancer. There are...
20 Jun 2011
Kevin DA, Meujo DAF, Hamann MT. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites. Expert Opinion on Drug Discovery 2009 Feb;4(2):109-146(38). doi:10.1517/17460440802661443. During this week’s TB R&D Weekly...
